Cole (Judah Lewis) is madly in love with his babysitter (Samara Weaving) Bee. She's hot, funny, and popular. One night, in a moment of defiance, Cole secretly stays up his bedtime to discover she's actually a cold-blooded killer who's in league with the Devil. He now must spend his night evading Bee's band of killers who will stop at nothing to prevent Cole from spilling their dark secret. It's up to Cole to survive the night (and blow up a few people along the way).

After super-villain Megamind (Ferrell) kills his good-guy nemesis, Metro Man (Pitt), he becomes bored since there is no one left to fight. He creates a new foe, Titan (Hill), who, instead of using his powers for good, sets out to destroy the world, positioning Megamind to save the day for the first time in his life.